protein production

Affinity Molecules offers custom cell line generation services spanning expression construct generation to manufacturing-grade, GMP-amenable CHO-based cell lines for antibody and biologic production. It also provides protein and antibody production and purification services, customized biological assay development, and mycoplasma detection services. The team was awarded an NIH Phase I grant for large scale in vitro production of capped polyadenylated mRNA-based vaccines.

antibody productionantibody purificationbacterial expression systemscell-based assayscell line generationELISAFlow Cytometrygene synthesisinducible expressioninsect expression systemsmammalian expression systemsPCR-based mycoplasma detectionplasmon resonanceprotein characterizationprotein purificationstable expressiontransient expression

BioAscent is a provider of integrated drug discovery services based at the former Organon/MSD R&D site in Newhouse, Scotland, UK. Founded in 2013, its services include assay development, target analysis, compound screening, medicinal and synthetic chemistry, computational chemistry, DMPK, protein science and compound management, with access to in-house diversity and fragment libraries.

assay developmentbiophysicscompound managementcompound screeningcompound storage and logisticscomputational chemistryDMPKhigh throughput screeningin silico discoveryLC-MSliquid handlingmedicinal chemistryNMRpurificationstructural biologysurface plasmon resonancesynthetic chemistry

CDI Labs provides proteomic products and services for autoantibody profiling, biomarker discovery, target identification, and antibody development. Its platforms include the HuProt™ Human Proteome Microarray (21,000+ full-length human proteins) and PhIP-Seq services such as HuScan®, MouseScan™, VirScan®, and VirScan® Exposome. The company also offers specialized CRO services including antibody development, protein production, cell therapy, and immunogenicity testing.

antibody developmentbiomarker discoverycell therapyCRISPR-Cas9 immunogenicity testingdiagnostic developmentimmunogenicity testingmolecular glue discoverypan-proteome epitope mappingPhIP-Seqpost-translational modification specificity profilingprotein microarrayproteome-wide autoantibody profilingtarget identification

Clarus Biologics is dedicated to the discovery and development of novel vaccine and immunology technologies. Launched in Q4 2019, its lead product is CBI-3A, a next-generation Virus Like Particle (VLP) vaccine adjuvant that elicits immune responses from all three elements of the adaptive immune system and has been studied in multiple animal species.

licensingpre-clinical studiesvaccine adjuvant developmentVLP technology

DAPCEL, Inc. is a research biotechnology company focused on developing strategies for optimization of enhanced protein production in any desired host organism. It uses a unique gene redesign approach accounting for rare codons and translation kinetics guided by synonymous codon usage for protein folding, yielding high levels of correctly folded soluble proteins. DAPCEL is a provider of mRNA codon optimization for mRNA vaccine applications.

bio-activity test developmentcodon usage optimizationgene optimizationmolecular cloningmRNA codon optimizationprotein expression testingprotein purification

Expression Systems, an Advancion company headquartered in Davis, California, supplies and services the baculovirus, cell culture and bio-industrial markets with cell culture media formulations, cell lines, molecular tools, reagents, and contract manufacturing services. Founded in 1997, the company specializes in the baculovirus expression vector system (BEVS) and insect cell culture, offering products and services from gene optimization to protein purification.

baculovirus stock productionbaculovirus titeringcell culture media manufacturingcodon optimizationcontract manufacturinggene synthesisGMP manufacturingmolecular biologyplasmid scale up and purificationprotein purificationvector design and cloning

Helix BioStructures is a contract research organization (CRO) headquartered in Indianapolis, Indiana, providing gene-to-structure services including protein production, biophysical characterization, cryo-EM, protein crystallography, X-ray data collection, and LNP characterization. Founded in 2017, it partners with biopharmaceutical and agricultural scientists through a co-sourcing model.

biophysical characterizationcryo-EMgene construct designLNP characterizationprotein crystallographyprotein expressionprotein purificationX-ray data collection

IRBM is a preclinical drug discovery organization based in Rome, Italy, conducting small molecule, peptide and antibody programs from target validation through to a preclinical candidate, either as a full integrated program or as a single capability for clients. Its scientists have contributed to three approved drugs and delivered more than thirty preclinical candidates to partners.

ADMEantibody phage displayassay developmentBioinformaticsbiophysical characterizationcompound managementcomputational chemistryDMPKfunctional genomicshigh-content screeninghigh throughput screeningin vivo pharmacologymedicinal chemistrymRNA displayNMRpeptide chemistrypeptide phage displaystructural biologysynthetic chemistry