oligonucleotide synthesis

ADViRNA is a boutique contract research organization (CRO) specializing in RNAi and oligonucleotide therapeutics. It provides oligonucleotide design, synthesis, screening, custom assay development, and siRNA reagents, supporting research from target identification to in vivo validation.

ASO designchemical modificationsconjugationcustom assay developmentduplex annealingHPLC and Mass Spec verificationin vivo validationoligonucleotide designoligonucleotide screeningsiRNA design

APTAGEN Labs is a biotechnology and life-sciences company focused on synthetic biology, described as a global leader in developing DNA-based antibodies called aptamers, with over 30 years of experience. Aptamers are target-recognition elements with high affinity and specificity against small molecules, protein biomarkers, cells, and tissues, serving as an alternative to antibodies for diagnostic, therapeutic, and bio-industrial applications. Aptagen was formed in 2004, with operations beginning in 2006, and is located in Jacobus, PA.

AI-supported bioinformatics analysisaptamer R&DCD spectraFlow Cytometrygel-shift assayhigh throughput screeningMicroscopymonoclonal aptamer synthesisNextGen sequencingSELEX screening/selectionSPR

Bioneer Inc. is the wholly owned American subsidiary of Bioneer Corporation, a Korean biotechnology company established in 1992. Located in a 14,000 square foot production and distribution facility in Alameda, CA, the company provides molecular biology products and technologies to life science researchers in academia, biotech and pharmaceutical companies, including oligonucleotides, thermostable polymerases, and instruments for gene manipulation.

cloningDNA manufacturinggene synthesispoint mutationrecombinant protein fermentation and purificationsiRNA synthesis

Bio-Synthesis is a U.S.-based custom synthesis and chemistry development CDMO supporting nucleic acids, peptides, bioconjugation, molecular biology services, analytical testing, scale-up, and therapeutic development workflows. Founded in 1984, it operates a 75,000 sq. ft. facility in Lewisville, Texas, with cGMP-aligned manufacturing from preclinical to commercial scale.

analytical testingbioconjugationcGMP manufacturingHPLC purificationmass spectrometry (MALDI-TOF, LC-MS, ESI)molecular biologyPAGE purificationpeptide synthesisscale-up manufacturingtangential-flow filtrationUV spectrophotometry