molecular docking

Alteron Therapeutics develops first-in-class TDP-43 inhibitors, the ALTA drug series, to find cures for neurodegeneration and cystic fibrosis. The company targets TDP-43 toxicity, which contributes to ALS, Alzheimer's disease, and frontotemporal lobar degeneration. Its leading drug candidate is orally bioavailable, crosses the blood-brain barrier, and shows potential to reverse ALS symptoms.

drug developmentNMR structuresTDP-43 inhibition

BioSolveIT develops drug discovery software, including SeeSAR, infiniSee, and HPSee, that enables chemists to screen ultra-large Chemical Spaces, perform molecular docking, and visualize binding poses. The company states its software is developed in Germany and aims to enable drug design for everyone.

3D virtual screeningADME predictionbinding site analysisChemical Space Dockingchemical space generationfragment-based drug discoveryhigh-performance computingscaffold-hopping

ChemDiv is a fully integrated target-to-clinic contract research organization (CRO) that has worked for over 32 years on drug discovery programs for cancer, neurological, infectious, cardiometabolic and immune diseases with pharma, biotech and academic partners. It offers integrated drug discovery services including custom chemistry, HTS, CADD, ADME, DMPK, discovery biology and preclinical services.

ADME/DMPK testinganimal modelscombinatorial chemistrycustom chemistryhigh throughput screening (HTS)in silico drug design (CADD)in vitro assaysin vivo studieslibrary designmedicinal chemistrymolecular dynamicspharmacokinetic studiestoxicology studiesvirtual screening

Enamine is a chemistry research organization and CRO that has been accumulating chemical knowledge and experience since 1991. It provides integrated drug discovery services, compound library synthesis, custom synthesis, FTE chemistry support, CADD, biology, and hit follow-up support, backed by over 650 chemists and the world's largest collection of building blocks.

1H NMRADMET profilingasymmetric synthesiscustom synthesiselectrochemistryfluorination with SF4free energy perturbationhigh-pressure hydrogenationHTSLCMS quality controllibrary synthesismolecular dynamicsparallel synthesisphotochemistry in flowQSAR modelingreversed-phase preparative HPLC purificationvirtual screening