downstream processing

Arzeda is a protein design company that uses its Intelligent Protein Design Technology™, combining physics-based protein design and AI algorithms, to create and manufacture new designer proteins and enzymes. Founded in 2009 by David Baker, Alexandre Zanghellini, and colleagues from the Institute for Protein Design at the University of Washington, it develops products for food & nutrition, home & personal care, advanced materials, and pharma.

AI-driven protein designcomputational protein designfermentationformulation developmentmachine learningmanufacturing scale-upphysics-based protein designstrain engineering

Avid Bioservices is a U.S.-based biologics CDMO providing integrated mammalian cell culture process development, analytical development, formulation development, and CGMP biologics manufacturing from DNA to IND to commercial supply. It operates FDA-inspected CGMP facilities in California, including an early-phase center in Costa Mesa and commercial manufacturing in Tustin.

analytical developmentcell line developmentCGMP clinical manufacturingCGMP commercial manufacturingcontinuous processingfed-batch manufacturingformulation developmentmammalian cell cultureperfusion systemsprocess developmentTech transferupstream processing

Callaghan Innovation is Aotearoa New Zealand's innovation agency, supporting businesses to turn ideas into commercial success through research and development expertise, funding, and connections. Named after Sir Paul Callaghan, it has supported innovators and entrepreneurs, helping advance R&D and commercialisation. It is now being disestablished as part of wider changes to the science, innovation and technology system, with services transferring to other organisations.

analytical servicesanti-microbial testingbench-scale researchbioactivity testingbioassays and analysisbioprocessingfermentationmicrobial screeningpilot to semi-commercial scale manufacturingprotein engineeringprotein extractionscale-up trialssolvent and supercritical extraction

Cirsium Biosciences develops viral vector production methods and systems using whole plants as bioreactors, aiming to democratize gene therapy through transformative manufacturing methods. The company was founded in 2019 (formerly known as Vecprobio, Inc.) and is based in San Diego, CA. Its plant-based platform uses a linear scale-out production model and controlled environment agriculture to produce recombinant AAV vectors.

controlled environment agriculture (CEA)fermentationlinear scale-out productionrecombinant AAV vector productionviral vector manufacturingwhole-plant bioreactor production

Enquyst Technologies is a biotechnology company that is disrupting the way biological drugs are manufactured. It has developed next-generation biomanufacturing technology solutions to enable continuous manufacturing and to give life-changing and curative treatments a viable path to the clinic with affordable costs. Its IPP technology replaces ProA, CEX and AEX chromatography unit operations, significantly reducing downstream processing costs.

biomanufacturing technologycontinuous manufacturing